Newer Antiepileptic Drugs and Cognitive Issues
نویسندگان
چکیده
منابع مشابه
Newer antiepileptic drugs
Epilepsy is a very common neurological disorder with high prevalence and incidence. Several conventional antiepileptic drugs are being used for the treatment of various types of epilepsies. Over the last two decades, there has been a rapid expansion in the number and types of available antiepileptic drugs (AED). Newer AEDs are now available for the treatment of various forms of epilepsies. Lamo...
متن کاملAre newer antiepileptic drugs associated with improved safety in pregnancy compared to older antiepileptic drugs?
Commentary As a group, antiepileptic drugs (AEDs) are associated with an increased risk of major congenital malformations (MCMs) (1). Older AEDs are the best studied. Valproate (VPA) is consistently associated with an increased risk of MCMs including an increased risk of spina bifida (2). Phenobarbital (PB) exposure increases the risk of MCMs, including oral clefts (3). Although not consistent ...
متن کاملNeuroprotective effects of some newer and potential antiepileptic drugs
Experimental models of epilepsy or status epilepticus (SE) provide evidence that seizures result in diffuse brain damage. Other neurological conditions are also associated with neurodegeneration, for example, stroke, head injury and chronic neurodegenerative diseases. In this review, the neuroprotective effects of a number of newer or potential antiepileptic drugs (AEDs) are considered in gener...
متن کاملCognitive Effects of Antiepileptic Drugs
Antiepileptic drugs (AEDs) can adversely affect cognitive function by suppressing neuronal excitability or enhancing inhibitory neurotransmission. The main cognitive effects of AEDs are impaired attention, vigilance, and psychomotor speed, but secondary effects can manifest on other cognitive functions. Although the long-term use of AEDs can obviously elicit cognitive dysfunction in epilepsy pa...
متن کاملCognitive functions, epileptic syndromes and antiepileptic drugs.
Cognitive function of patients on monotherapy specific for their epileptic syndrome has been studied infrequently. We evaluated 7 patients with symptomatic localised epilepsies (SEL) on phenytoin aged 30 +/- 12 (mean +/- standard deviation) years, 8 with idiopathic generalised epilepsies on sodium valproate aged 18 +/- 4 years, 16 with SEL on carbamazepine aged 28 +/- 11 years, and 35 healthy c...
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ژورنال
عنوان ژورنال: Epilepsia
سال: 2003
ISSN: 0013-9580,1528-1167
DOI: 10.1046/j.1528-1157.44.s4.3.x